Key result
Serum uric acid was positively associated with pulse-wave velocity (β = 0.27; P=0.01) and ambulatory arterial stiffness index (β = 0.11; P=0.03) in women after adjusting for classical risk factors.
Why the study?
Does serum uric acid level correlate with vascular structure and function in hypertensive patients, and are there sex-related differences?
Cross-Sectional (n=366)
Does serum uric acid level correlate with vascular structure and function in hypertensive patients, and are there sex-related differences?
Effect estimate: β = 0.27
p-value: p=0.01
Serum uric acid levels are associated with markers of arterial stiffness in hypertensive patients, with notable sex-related differences such as a positive association with pulse-wave velocity and ambulatory arterial stiffness index in women.
UA-vascular associations in hypertension should not yet inform practice; leaves open causality and sex-specific effects for prospective studies.
BACKGROUND: We sought to analyze the relationship between uric acid (UA) and vascular structure and function based on the carotid intima-media thickness, the pulse-wave velocity (PWV), the central arterial pressure, and the augmentation index in hypertensive patients and to evaluate the sex-related differences. METHODS: A cross-sectional study was performed with 366 hypertensive individuals aged 34-75 years (men = 61.74%). The vascular structure was assessed based on the carotid intima-media thickness, the arterial stiffness was assessed by PWV, and the vascular function was assessed using hemodynamic parameters such as the central and peripheral augmentation index and the ambulatory arterial stiffness index (AASI). RESULTS: In the bivariable analysis, the PWV (r = 0.28; P < 0.01) and AASI (r = 0.25; P < 0.01) were positively correlated with UA in women. The central augmentation index (r = -0.16; P < 0.05) and peripheral augmentation index (r = -0.18; P < 0.05) were negatively correlated with UA, whereas the maximum carotid intima-media thickness (r = 0.11; P < 0.05) was positively correlated with UA in the global analysis. In the multiple linear regression analysis, a positive association between PWV and UA was observed after adjusting for classical risk factors (β = 0.27; P = 0.01) in women only. In turn, a negative association was observed between the AASI and UA after adjusting for confounders in men (β = -0.06; P = 0.04), with a positive association in women (β = 0.11; P = 0.03). CONCLUSIONS: Serum UA showed a positive correlation with the mean maximum intima-media thickness and PWV, and this parameter showed a negative correlation with the central and peripheral augmentation indices, although this relationship was lost after adjusting for confounding factors. AASI showed a positive association in women and a negative association in men after adjusting for confounding factors. CLINICAL TRIALS REGISTRATION: Clinical Trials.gov Identifier: NCT01325064.
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Gómez‐Marcos et al. (2013) conducted a cross-sectional in Hypertension (n=366). Serum uric acid was evaluated on Vascular structure and function (pulse-wave velocity and ambulatory arterial stiffness index) (β = 0.27, p=0.01). Serum uric acid was positively associated with pulse-wave velocity (β = 0.27; P=0.01) and ambulatory arterial stiffness index (β = 0.11; P=0.03) in women after adjusting for classical risk factors.
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