Key result
Sensory nerve-dependent vasodilation was normal in Zucker diabetic fatty rats compared to controls (64% vs 59% maximal response to Ca2+, P=NS), whereas endothelium-dependent relaxation was impaired.
Absolute Event Rate: 64% vs 59%
p-value: p=NS
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Preserved sensory nerve relaxation in diabetic rat arteries despite endothelial impairment; leaves open relevance to human diabetic vasculopathy.
Pamarthi et al. (2002) studied Type II diabetes. Type II diabetes (ZDF rat model) vs. Genetic controls was evaluated on Sensory nerve-dependent vasodilation (maximal relaxation response to Ca2+) (p=NS). Sensory nerve-dependent vasodilation was normal in Zucker diabetic fatty rats compared to controls (64% vs 59% maximal response to Ca2+, P=NS), whereas endothelium-dependent relaxation was impaired.
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