Why the study?
Does prolonged hyperglycemia or compromised beta-cell function alter endothelial- and nonendothelial-dependent dilation of the intestinal microvasculature in Zucker fatty diabetic rats?
Does prolonged hyperglycemia or compromised beta-cell function alter endothelial- and nonendothelial-dependent dilation of the intestinal microvasculature in Zucker fatty diabetic rats?
Prolonged hyperglycemia in hyperinsulinemic rats does not impair intestinal microvascular dilation, but compromising beta-cell function substantially impairs endothelial-dependent dilation.
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Hyperglycemia alone may spare endothelial function in insulin-resistant models; leaves open beta-cell dysfunction as driver of microvascular impairment pending human validation.
Bohlen et al. (1995) studied this question.
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