Key result
Mutations in the ryanodine receptor type 1 (RyR1) associated with malignant hyperthermia enhance sensitivity to caffeine and halothane in skeletal muscle.
Population
Skeletal muscle models expressing six ryanodine receptor isoform-1 mutations associated with malignant…
Design
Preclinical
Authors
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Some MHRyR1 mutations increase caffeine/halothane sensitivity in expression systems; leaves open clinical translation for MH diagnostics.
RyR1 mutations associated with malignant hyperthermia alter skeletal excitation-contraction coupling by enhancing sensitivity to caffeine and halothane.
Yang et al. (2003) studied Malignant hyperthermia. RyR1 mutations was evaluated. Mutations in the ryanodine receptor type 1 (RyR1) associated with malignant hyperthermia enhance sensitivity to caffeine and halothane in skeletal muscle.
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