Key result
The SRm160/300 splicing coactivator is required for a purine-rich exonic splicing enhancer to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene.
The SRm160/300 splicing coactivator promotes critical interactions between ESE-bound activators and the snRNP machinery of the spliceosome.
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May inform splicing-targeted therapies; leaves open validation in human cardiovascular models.
Eldridge et al. (1999) studied this question. SRm160/300 splicing coactivator was evaluated on Splicing of pre-mRNA. The SRm160/300 splicing coactivator is required for a purine-rich exonic splicing enhancer to promote the splicing of a pre-mRNA derived from the Drosophila doublesex gene.
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