MHC-Antigens: Constituents of the Envelopes of Human and Simian Immunodeficiency
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Discussion
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Implication
Immunoelectron microscopy reveals MHC antigens in HIV and SIV, suggesting impacts on diagnostics.
Key Points
- The aim is to explore the antigenic composition of HIV and SIV, particularly MHC class I and II components.
- Utilized immunoelectron microscopy to analyze virus samples grown in Molt-3 and H9 cells.
- Employed antibodies targeting HIV surface glycoprotein gp120 and MHC class I and II antigens.
- gp120 was weakly indicated on mature virions.
- MHC class I determinants were consistently present in small amounts on HIV and SIV.
- High-density MHC class II antigens were found in HIV and SIV grown in H9 cells but absent in those grown in Molt-3 cells.
Cite This Study
Gelderblom et al. (1987) studied this question.