Every 1-point increase in the Cardiovascular Profile Score at first echocardiogram was independently associated with increased odds of perinatal survival (adjusted OR 2.0; 95% CI 1.3-3.2; p=0.003).
Cohort (n=164)
Yes
Does the Cardiovascular Profile Score predict perinatal survival in fetuses with Ebstein's anomaly or tricuspid valve dysplasia?
The Cardiovascular Profile Score serves as an independent predictor of perinatal survival in fetuses with Ebstein's anomaly or tricuspid valve dysplasia.
Odds Ratio: 2 (95% CI 1.3–3.2)
p-value: p=0.003
OBJECTIVE: We sought to perform multi-variable modeling to assess the independent value of the CVPS in fetuses with Ebstein anomaly or tricuspid valve dysplasia (EA/TVD). METHODS: CVPS was assessed at a core lab using the first and last echocardiograms during gestation. A receiver operating characteristic (ROC) curve analysis was conducted. Changes in the CVPS from the first to the last echo were assessed with Wilcoxon signed-rank tests. RESULTS: There were 164 fetuses with EA/TVD with complete CVPS at the first echo. Nearly half, 48.8% (n = 80), had intrauterine fetal demise (IUFD) or died neonatally. At the first echo, median gestational age (GA) was 27.6 weeks (IQR: 23.0-31.0) and median CVPS was 7 (IQR: 6-8). The optimal cut-point for classification of perinatal survival was observed at CVPS ≥ 6.5 (Youden index = 0.46). After adjustment, there remained a significant independent association between every 1-point increase in the CVPS at first echo and the odds of perinatal survival (adjusted odds ratio: 2.0, 95% CI: 1.3 to 3.2, and p = 0.003). The CVPS at the last echo decreased by a median of 1 point among both survivors (p < 0.01) and non-survivors (p < 0.001). CONCLUSION: Among fetuses with EA/TVD, the CVPS may be used as an additional tool to assess perinatal survival throughout gestation.
Freire et al. (Tue,) conducted a cohort in Ebstein's anomaly or tricuspid valve dysplasia (n=164). Cardiovascular Profile Score (CVPS) vs. Lower CVPS was evaluated on Perinatal survival (adjusted OR 2.0, 95% CI 1.3 to 3.2, p=0.003). Every 1-point increase in the Cardiovascular Profile Score at first echocardiogram was independently associated with increased odds of perinatal survival (adjusted OR 2.0; 95% CI 1.3-3.2; p=0.003).