Key result
Fetuses with uncontrolled arrhythmia at birth had significantly lower cardiovascular profile scores and higher umbilical vein natriuretic peptide levels than other groups and controls (p < .01).
Why the study?
To evaluate the clinical significance of natriuretic peptide levels in fetal arrhythmia.
Do umbilical vein natriuretic peptide levels reflect heart failure status and response to therapy in fetuses with arrhythmia?
Observational (n=173)
Do umbilical vein natriuretic peptide levels reflect heart failure status and response to therapy in fetuses with arrhythmia?
p-value: p=< .01
Umbilical vein natriuretic peptide concentrations at birth effectively reflect the severity of fetal heart failure and the response to fetal antiarrhythmic therapy.
UV NP levels may complement CVP scoring in fetal arrhythmia; leaves open prospective validation before guiding therapy.
Objectives To evaluate the significance of natriuretic peptide (NP) levels in fetal arrhythmia.Study design Cardiovascular profile (CVP) scores and umbilical vein (UV) NP levels at birth were compared by different fetal arrhythmia statuses.Results Fetal tachyarrhythmia (n = 22), bradyarrhythmia (n = 12), extrasystole (n = 12) and controls (n = 127) were enrolled in this study. Fetal antiarrhythmic therapy was performed in fetuses with tachyarrhythmia (n = 18) and bradyarrhythmia (n = 5). Fetal arrhythmias were divided into three groups: group A (arrhythmia controlled at birth, n = 17), Group B (arrhythmia uncontrolled at birth, n = 9) and Group C (fetal therapy not indicated, n = 20). Group B had significantly lower CVP scores and higher NP levels than the other two groups and controls (p < .01). Groups A and C had significantly lower CVP scores than controls, but NP levels in Groups A and C showed no differences compared with controls.Conclusions UV NP concentrations reflect the severity of fetal arrhythmia and responses to fetal therapy.
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Miyoshi et al. (2019) conducted an observational in Fetal arrhythmia (n=173). Fetal arrhythmia status (uncontrolled) vs. Controls and fetuses with controlled arrhythmia was evaluated on Cardiovascular profile (CVP) scores and umbilical vein (UV) NP levels at birth (p=< .01). Fetuses with uncontrolled arrhythmia at birth had significantly lower cardiovascular profile scores and higher umbilical vein natriuretic peptide levels than other groups and controls (p < .01).
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