Key result
Plasma ANP levels were similar between fetuses with cardiac abnormalities and controls overall (p=0.18), but were significantly higher in the subset with concurrent polyhydramnios.
Observational (n=41)
Answers are grounded in this paper and cite their sources.
Polyhydramnios in fetuses with heart conditions may be driven by increased fetal diuresis secondary to elevated ANP production.
OBJECTIVE: To investigate atrial natriuretic peptide (ANP) levels in fetuses with cardiac defects and to evaluate the relationships between plasma ANP levels and the presence of polyhydramnios. METHODS: Plasma ANP levels were measured by radioimmunoassay in 27 fetuses with cardiac abnormalities and in 14 normal healthy fetuses. RESULTS: Fetal plasma ANP levels were similar in the two studied groups (p = 0.18) but they were significantly higher in a subset of cases with cardiac disease and polyhydramnios (n = 7) than in those with cardiac disease and normal amniotic fluid (n = 20; p = 0.036) and controls (p = 0.01). CONCLUSION: Polyhydramnios in fetuses with heart conditions might be explained by increased fetal diuresis secondary to increased ANP production.
No takes yet. Share an insight, caveat, or question.
Bartha et al. (2005) conducted an observational in Cardiac disease (n=41). Cardiac abnormalities vs. Normal healthy fetuses was evaluated on Plasma atrial natriuretic peptide (ANP) levels (p=0.18). Plasma ANP levels were similar between fetuses with cardiac abnormalities and controls overall (p=0.18), but were significantly higher in the subset with concurrent polyhydramnios.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: