Key result
Natriuretic peptide levels, particularly NT-proBNP in umbilical cord blood and amniotic fluid, reflect the severity of fetal heart failure and can serve as diagnostic biomarkers.
Why the study?
Assessing fetal heart failure severity by ultrasonography is difficult, and studies investigating natriuretic peptide levels and metabolism in fetuses and amniotic fluid are limited.
Can natriuretic peptide measurements in umbilical cord blood and amniotic fluid serve as diagnostic biomarkers for fetal heart failure?
Can natriuretic peptide measurements in umbilical cord blood and amniotic fluid serve as diagnostic biomarkers for fetal heart failure?
Natriuretic peptide measurements in umbilical cord blood and amniotic fluid may serve as useful diagnostic biomarkers for fetal heart failure.
Fetal heart failure is mainly caused by congenital heart defect and arrhythmia. It is difficult to appropriately diagnose the severity of fetal heart failure simply by ultrasonography because the development of a fetal heart in fetoplacental circulation and how well the fetal myocardium can adapt to postnatal cardiopulmonary circulation are challenging to assess. In adult cardiology, natriuretic peptides (NPs) are the most useful biomarker of heart failure; however, studies investigating NP levels in the fetuses and amniotic fluid are quite limited. Furthermore, little is known about their production and metabolism. This review summarized the most relevant findings on NP levels in the umbilical cord blood and amniotic fluid. The findings can then extend their use as a diagnostic biomarker of heart failure in fetuses with congenital heart defect and/or arrhythmia.
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Miyoshi et al. (2021) conducted a review in Fetal heart failure. Natriuretic peptide measurements was evaluated. Natriuretic peptide levels, particularly NT-proBNP in umbilical cord blood and amniotic fluid, reflect the severity of fetal heart failure and can serve as diagnostic biomarkers.
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