Key result
Amniotic fluid ANP concentrations were significantly higher at term than in mid-pregnancy, though they represent different molecular forms than plasma ANP.
Observational (n=21)
ANP immunoreactivity in amniotic fluid is present but consists of different molecular forms than the main component found in maternal plasma.
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Hypothesis-generating for amniotic fluid ANP in pregnancy; should not yet alter clinical management of hypertension.
Concentrations of atrial natriuretic peptide (ANP) were measured in amniotic fluid and maternal plasma during normal pregnancy. Amniotic fluid samples were obtained from 12 non-laboring women during mid-gestational amniocentesis and from 9 laboring women at term during artificial rupture of the membranes. ANP concentrations in amniotic fluid were low in relation to those in plasma, although significantly higher at term than in mid-pregnancy. However the results of subsequent high-pressure- liquid-chromatography analysis suggest that ANP immunoreactivity in amniotic fluid must be attributed to other molecular forms than the main immunoreactive component of ANP present in plasma.
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Steegers et al. (1991) conducted an observational in Normal pregnancy (n=21). Term pregnancy (laboring) vs. Mid-pregnancy (non-laboring) was evaluated on ANP concentrations in amniotic fluid. Amniotic fluid ANP concentrations were significantly higher at term than in mid-pregnancy, though they represent different molecular forms than plasma ANP.
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