American Heart Association's Life's Simple 7 and Risk of Venous Thromboembolism: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Key result
An optimal Life's Simple 7 cardiovascular health score was associated with a 44% lower risk of incident venous thromboembolism compared to an inadequate score (HR 0.56; 95% CI 0.38-0.82).
Why the study?
Does a favorable Life's Simple 7 score reduce the risk of incident venous thromboembolism in adults ≥45 years of age?
Population
30,239 black and white participants ≥45 years of age across the United States
Comparison
Optimal or average Life's Simple 7 score vs Inadequate (0 to 4 points) Life's Simple 7 score
Design
Cohort
Follow-up
5.0 years
Authors
Discussion
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Implication
Suggests traditional cardiovascular health optimization may also mitigate venous thromboembolic risk; extends the utility of AHA.
Study Design
Type
Cohort (n=30,239)
Multicenter
Yes
Structured PICO
Does a favorable Life's Simple 7 score reduce the risk of incident venous thromboembolism in adults ≥45 years of age?
P
Population
30,239 black and white adults aged ≥45 years across the United States, followed for 5.0 years to assess the association between Life's Simple 7 scores and incident VTE.
E
Exposure
Optimal (10 to 14 points) or average (5 to 9 points) Life's Simple 7 score
C
Comparator
Inadequate (0 to 4 points) Life's Simple 7 score
O
Outcome
Incident venous thromboembolism (VTE)hard clinical
Main Result
Hazard Ratio: 0.56 (95% CI 0.38–0.82)
Absolute Event Rate: 1.8% vs 2.9%
Favorable cardiovascular health, as measured by the AHA's Life's Simple 7 metric, is associated with a significantly reduced risk of incident venous thromboembolism.
Cite This Study
Olson et al. (2015) conducted a cohort in Venous thromboembolism (n=30,239). Optimal Life's Simple 7 score vs. Inadequate Life's Simple 7 score was evaluated on Incident venous thromboembolism (HR 0.56, 95% CI 0.38-0.82). An optimal Life's Simple 7 cardiovascular health score was associated with a 44% lower risk of incident venous thromboembolism compared to an inadequate score (HR 0.56; 95% CI 0.38-0.82).