Following deep vein thrombosis, mean SF-36 physical and mental QOL scores improved by 5.1 and 4.6 points over 4 months (P<0.001), but remained lower than population norms.
Cohort (n=359)
Yes
Quality of life generally improves over 4 months following deep vein thrombosis, but remains lower than population norms, with worsening postthrombotic syndrome predicting poorer QOL.
p-value: p=<.001
BACKGROUND: To our knowledge, the burden of deep venous thrombosis from the patient's perspective has not been quantified. We evaluated health-related quality of life (QOL) after deep vein thrombosis and compared results with general population norms. METHODS: This was a multicenter prospective cohort study of 359 consecutive eligible patients with deep vein thrombosis recruited at 7 Canadian hospital centers. Quality of life was assessed at baseline and at 1 and 4 months after diagnosis using generic (36-Item Short-Form Health Survey) and disease-specific (Venous Insufficiency Epidemiological and Economic Study VEINES-QOL and VEINES symptom VEINES-Sym questionnaires) measures. Changes in QOL scores during the 4-month period were calculated, and determinants of lack of improvement in QOL were evaluated. RESULTS: During the 4 months, mean 36-Item Short-Form Health Survey physical and mental component summary scores improved by 5.1 and 4.6 points, respectively, and VEINES-QOL and VEINES-Sym scores improved by 3.1 and 2.2 points, respectively (P < .001 for time trend for all measures). However, about one third of patients had worsening of QOL during follow-up. Multivariate analyses showed that worsening of the postthrombotic syndrome score was an independent predictor of worsening of 36-Item Short-Form Health Survey physical component summary (P = .04), VEINES-QOL (P < .001), and VEINES-Sym (P < .001) scores. The 36-Item Short-Form Health Survey physical component summary scores were lower than population norms at all points assessed. CONCLUSIONS: On average, QOL improves during the 4 months following deep vein thrombosis. However, in about one third of patients, QOL deteriorates, and at 4 months, average QOL remains poorer than population norms. Worsening of the postthrombotic syndrome score is associated with worsening of QOL.
Susan R. Kahn (Mon,) conducted a cohort in Deep venous thrombosis (n=359). Deep vein thrombosis vs. General population norms was evaluated on Change in 36-Item Short-Form Health Survey physical and mental component summary scores (p=<.001). Following deep vein thrombosis, mean SF-36 physical and mental QOL scores improved by 5.1 and 4.6 points over 4 months (P<0.001), but remained lower than population norms.
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