Prospective Evaluation of Health-Related Quality of Life in Patients With Deep Venous Thrombosis
Key result
Following deep vein thrombosis, mean SF-36 physical and mental QOL scores improved by 5.1 and 4.6 points over 4 months (P<0.001), but remained lower than population norms.
Population
359 consecutive eligible patients with deep vein thrombosis recruited at 7 Canadian hospital centers
Design
Cohort
Follow-up
4 months
Authors
Discussion
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Member takes
Implication
DVT impairs patient QOL at 1-4 months; leaves open whether targeted interventions improve outcomes.
Study Design
Type
Cohort (n=359)
Multicenter
Yes
Structured PICO
P
Population
359 consecutive patients with deep vein thrombosis followed for 4 months to evaluate health-related quality of life.
C
Comparator
General population norms
O
Outcome
Health-related quality of life (QOL) assessed at baseline, 1, and 4 months after diagnosis using generic (36-Item Short-Form Health Survey) and disease-specific (VEINES-QOL and VEINES-Sym) measurespatient reported
Main Result
p-value: p=<.001
Quality of life generally improves over 4 months following deep vein thrombosis, but remains lower than population norms, with worsening postthrombotic syndrome predicting poorer QOL.
Cite This Study
Susan R. Kahn (2005) conducted a cohort in Deep venous thrombosis (n=359). Deep vein thrombosis vs. General population norms was evaluated on Change in 36-Item Short-Form Health Survey physical and mental component summary scores (p=<.001). Following deep vein thrombosis, mean SF-36 physical and mental QOL scores improved by 5.1 and 4.6 points over 4 months (P<0.001), but remained lower than population norms.