The Quality of Life and Mental Health of Indian Patients with Postthrombotic Syndrome: Insights from a Tertiary Care Center

Objectives: The impact of post-thrombotic syndrome (PTS) on quality of life (QoL) remains unclear in lower-middle income countries. We assessed the quality of life and determining factors for PTS in an Indian demographic. Materials and Methods: Patients diagnosed with PTS between March and July 2023 were reviewed. The severity of PTS, QoL, mental health, and socioeconomic status was assessed with Villalta score, disease-specific Veines QoL score, patient health questionnaire, and modified BG Prasad scale, respectively. Results: Fifty-four patients (68.5% males, mean age of 43.8 ± 12.46 years) were enrolled after a mean time after deep vein thrombosis (DVT) of 42.33 ± 40.1 months. The DVTs were in the femoropopliteal (63%) and iliofemoral segments (37%). The most common causes of provoked DVTs (46.3%) were posttrauma immobilization (11.1%) and thrombophilias (11.11%). The average QoL was 50.17. A significant correlation between the severity of PTS and QoL scores was present ( r = −0.629; P < 0.001). There was a 40.7% incidence of clinical depression which significantly lowered QoL scores ( r = −0.418; P = 0.002). The determinants that significantly impacted QoL included time after DVT ( r = −0.27; P = 0.043) and pulmonary embolism ( P = 0.004). Conclusion: Among an Indian population, PTS significantly impairs QoL and mental health with a progressive decline in QoL over time.