What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Post-thrombotic syndrome following deep vein thrombosis (n=88). Intervention: Younger age vs. Older age. Primary outcome: Post-thrombotic syndrome (PTS) diagnosed by predefined clinical criteria (OR 0.96, 95% CI 0.93-0.99, p=0.01).

May 23, 2020Open Access

Younger age (OR 0.96) and higher baseline Villalta score (OR 1.23) were independent predictors of developing post-thrombotic syndrome in a long-term follow-up of patients with high proximal deep vein thrombosis.

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Why the study?

Post-thrombotic syndrome is a frequent chronic complication of proximal deep vein thrombosis, but its predictors are not well established.

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a history of first time acute upper femoral or iliofemoral DVT

Comparison

Predictors of PTS vs no PTS

Design

Cross-sectional study

Follow-up

8-10 years

Key result

Younger age (OR 0.96) and higher baseline Villalta score (OR 1.23) were independent predictors of developing post-thrombotic syndrome in a long-term follow-up of patients with high proximal deep vein thrombosis.

Authors

MEMarit Engeseth TETone Enden PSPer Morten Sandset

Discussion

Member takes

Overview

Identifies potential long-term predictors of post-thrombotic syndrome following proximal DVT;.

Study Design

Type

Cross-Sectional (n=88)

Structured PICO

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a previous first-time acute upper femoral or iliofemoral DVT were evaluated 8-10 years later to identify predictors of long-term post-thrombotic syndrome.

Outcome

Post-thrombotic syndrome (PTS) defined by four mandatory clinical criteriacomposite

Main Result

Odds Ratio: 0.96 (95% CI 0.93–0.99)

p-value: p=0.01

Younger age and higher baseline Villalta score at the time of DVT diagnosis independently predict the development of long-term post-thrombotic syndrome.

Limitations

PTS assessment used a non-validated diagnostic tool based on four clinical criteria.
Only 52% of eligible patients participated, introducing potential selection bias.
A single study investigator performed all study visits and assessments.
Inability to assess BMI as height and weight were not systematically collected at baseline.
Pelvic involvement was not routinely assessed in patients randomized to the control group.

Cite This Study

Engeseth et al. (2020) conducted a cross-sectional in Post-thrombotic syndrome following deep vein thrombosis (n=88). Younger age vs. Older age was evaluated on Post-thrombotic syndrome (PTS) diagnosed by predefined clinical criteria (OR 0.96, 95% CI 0.93-0.99, p=0.01). Younger age (OR 0.96) and higher baseline Villalta score (OR 1.23) were independent predictors of developing post-thrombotic syndrome in a long-term follow-up of patients with high proximal deep vein thrombosis.

synapsesocial.com/papers/6a9199b1963a1f481f33fe9a https://doi.org/10.21203/rs.3.rs-29584/v1

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May 23, 2020Open Access

Younger age (OR 0.96) and higher baseline Villalta score (OR 1.23) were independent predictors of developing post-thrombotic syndrome in a long-term follow-up of patients with high proximal deep vein thrombosis.

View Full Paper

Ask AI

Bookmark

Why the study?

Post-thrombotic syndrome is a frequent chronic complication of proximal deep vein thrombosis, but its predictors are not well established.

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a history of first time acute upper femoral or iliofemoral DVT

Comparison

Predictors of PTS vs no PTS

Design

Cross-sectional study

Follow-up

8-10 years

Key result

Authors

MEMarit Engeseth TETone Enden PSPer Morten Sandset

Discussion

Member takes

Overview

Identifies potential long-term predictors of post-thrombotic syndrome following proximal DVT;.

Study Design

Type

Cross-Sectional (n=88)

Structured PICO

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a previous first-time acute upper femoral or iliofemoral DVT were evaluated 8-10 years later to identify predictors of long-term post-thrombotic syndrome.

Outcome

Post-thrombotic syndrome (PTS) defined by four mandatory clinical criteriacomposite

Main Result

Odds Ratio: 0.96 (95% CI 0.93–0.99)

p-value: p=0.01

Younger age and higher baseline Villalta score at the time of DVT diagnosis independently predict the development of long-term post-thrombotic syndrome.

Limitations

PTS assessment used a non-validated diagnostic tool based on four clinical criteria.
Only 52% of eligible patients participated, introducing potential selection bias.
A single study investigator performed all study visits and assessments.
Inability to assess BMI as height and weight were not systematically collected at baseline.
Pelvic involvement was not routinely assessed in patients randomized to the control group.

Cite This Study

synapsesocial.com/papers/6a9199b1963a1f481f33fe9a https://doi.org/10.21203/rs.3.rs-29584/v1

Also Consider

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