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December 4, 2020Open Access

Younger age (OR 0.96, 95% CI 0.93-0.99, p=0.01) and higher baseline Villalta score (OR 1.23, 95% CI 1.02-1.49, p=0.03) were independent predictors of long-term post-thrombotic syndrome.

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Why the study?

Post-thrombotic syndrome (PTS) frequently complicates proximal DVT of the lower limb, but its predictors are not well established.

Population

88 patients with a first-time acute upper femoral or iliofemoral DVT

Comparison

Predictors of PTS vs no PTS

Design

Cross-sectional follow-up study

Follow-up

8-10 years

Authors

MEMarit EngesethTETone EndenPSPer Morten Sandset

Discussion

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Member takes

Overview

Should not yet change long-term PTS counseling after proximal DVT; leaves open confirmation of these predictors in broader populations.

Structured PICO

P
Population
88 patients with a first-time acute upper femoral or iliofemoral deep vein thrombosis (DVT) who were previously randomized in the CaVenT study, mean age 60.7 years at follow-up (50.5 at baseline), 35% female.
O
Outcome
Post-thrombotic syndrome (PTS) diagnosed by four mandatory predefined clinical criteria (objectively verified DVT, chronic complaints >1 month in DVT leg, complaints appeared after DVT, alternative diagnosis unlikely)composite

In patients with a history of high proximal DVT, younger age and a higher baseline Villalta score are independent predictors of developing long-term post-thrombotic syndrome.

Limitations

  • PTS assessment with no previously validated diagnostic tool
  • One study investigator performed all study visits and assessments
  • Only 52% of eligible patients gave consent to participate, introducing possible selection bias
  • Pelvic involvement was not routinely assessed in patients randomized to the control group
  • BMI was not systematically collected at baseline
  • No data on time in therapeutic range (TTR) to evaluate the quality of anticoagulation

Cite This Study

Engeseth et al. (2020) studied this question.

synapsesocial.com/papers/6a7fe6fc112716a4cb4a08ebhttps://doi.org/10.21203/rs.3.rs-29584/v3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study2020 · 1 citations
  2. 2Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study2020
  3. 3Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study2021 · 26 citations
  4. 4Post-thrombotic syndrome after early intervention in acute lower limb deep vein thrombosis: a retrospective cohort study2024
  5. 5New and known predictors of the postthrombotic syndrome: A subanalysis of the ATTRACT trial2022 · 15 citations