Key result
In a long-term follow-up of patients with proximal DVT, a higher baseline Villalta score and younger age were independent predictors of developing post-thrombotic syndrome.
Why the study?
Post-thrombotic syndrome is a frequent chronic complication of proximal lower limb deep vein thrombosis, but its predictors are not well established.
What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?
Cross-Sectional (n=88)
What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?
In patients with high proximal DVT, younger age and higher baseline Villalta score independently predict the development of long-term post-thrombotic syndrome.
Answers are grounded in this paper and cite their sources.
Younger age and higher baseline Villalta score were associated with long-term PTS; leaves open whether these predictors should guide targeted surveillance or prevention trials.
Background Post-thrombotic syndrome (PTS) is a frequent chronic complication of proximal deep vein thrombosis (DVT) of the lower limb, but predictors of PTS are not well established. We aimed to examine predictors of PTS in patients with long-term PTS following proximal DVT.Methods During 2006-09, 209 patients with a first time acute upper femoral or iliofemoral DVT were randomized to receive either additional catheter-directed thrombolysis or conventional therapy alone. In 2017, the 170 still-living participants were invited to participate in a cross-sectional follow-up study. In the absence of a gold standard diagnostic test, PTS was defined in line with clinical practice by four mandatory, predefined clinical criteria: 1. An objectively verified DVT; 2. Chronic complaints (>1 month) in the DVT leg; 3. Complaints appeared after the DVT; and 4. An alternative diagnosis was unlikely. Possible predictors of PTS were identified with multivariate logistic regression. Results 88 patients (52%) were included 8-10 years following the index DVT, and 44 patients (50%) were diagnosed with PTS by the predefined clinical criteria. Younger age and higher baseline Villalta score were found to be independent predictors of PTS, i.e., OR 0.96 (95% CI, 0.93-0.99), and 1.23 (95% CI, 1.02-1.49), respectively. Lack of iliofemoral patency at six months follow-up was significant in the bivariate analysis, but did not prove to be significant after the multivariate adjustments.Conclusions In long-term follow up after high proximal DVT, younger age and higher Villalta score at DVT diagnosis were independent predictors of PTS.
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Engeseth et al. (2020) conducted a cross-sectional in Post-thrombotic syndrome following proximal deep vein thrombosis (n=88). Higher baseline Villalta score vs. Lower baseline Villalta score was evaluated on Post-thrombotic syndrome (PTS) defined by four predefined clinical criteria (OR 1.23, 95% CI 1.02-1.49, p=0.03). In a long-term follow-up of patients with proximal DVT, a higher baseline Villalta score and younger age were independent predictors of developing post-thrombotic syndrome.
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