September 3, 2020Open Access

In a long-term follow-up of patients with proximal DVT, a higher baseline Villalta score (OR 1.23) and younger age (OR 0.96) were independent predictors of developing post-thrombotic syndrome.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Post-thrombotic syndrome following proximal deep vein thrombosis (n=88). Intervention: Higher baseline Villalta score vs. Lower baseline Villalta score. Primary outcome: Post-thrombotic syndrome (PTS) defined by four predefined clinical criteria (OR 1.23, 95% CI 1.02-1.49, p=0.03).

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Why the study?

Post-thrombotic syndrome is a frequent chronic complication of proximal lower limb deep vein thrombosis, but its predictors are not well established.

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a first time acute upper femoral or iliofemoral DVT

Comparison

Patients with PTS vs without PTS

Design

Cross-sectional follow-up study

Follow-up

8-10 years

Key result

In a long-term follow-up of patients with proximal DVT, a higher baseline Villalta score (OR 1.23) and younger age (OR 0.96) were independent predictors of developing post-thrombotic syndrome.

Authors

MEMarit Engeseth TETone Enden PSPer Morten Sandset

Discussion

Member takes

Overview

Younger age and higher baseline Villalta score were associated with long-term PTS; leaves open whether these predictors should guide targeted surveillance or prevention trials.

Study Design

Type

Cross-Sectional (n=88)

Structured PICO

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a history of first-time upper femoral or iliofemoral DVT were evaluated 8-10 years post-DVT to identify predictors of long-term post-thrombotic syndrome.

Outcome

Post-thrombotic syndrome (PTS) defined by four clinical criteria: objectively verified DVT, chronic complaints (>1 month) in the DVT leg, complaints appeared after DVT, and alternative diagnosis unlikely.

Main Result

Odds Ratio: 1.23 (95% CI 1.02–1.49)

p-value: p=0.03

In patients with high proximal DVT, younger age and higher baseline Villalta score independently predict the development of long-term post-thrombotic syndrome.

Limitations

PTS assessment was performed using a non-validated diagnostic tool based on clinical criteria.
Only 52% of eligible patients participated, introducing potential selection bias.
A single study investigator performed all study visits and clinical assessments.
Lack of data on BMI and time in therapeutic range (TTR) prevented their evaluation as predictors.

Cite This Study

Engeseth et al. (2020) conducted a cross-sectional in Post-thrombotic syndrome following proximal deep vein thrombosis (n=88). Higher baseline Villalta score vs. Lower baseline Villalta score was evaluated on Post-thrombotic syndrome (PTS) defined by four predefined clinical criteria (OR 1.23, 95% CI 1.02-1.49, p=0.03). In a long-term follow-up of patients with proximal DVT, a higher baseline Villalta score (OR 1.23) and younger age (OR 0.96) were independent predictors of developing post-thrombotic syndrome.

synapsesocial.com/papers/6a9199b1963a1f481f33fe98 https://doi.org/10.21203/rs.3.rs-29584/v2

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September 3, 2020Open Access

In a long-term follow-up of patients with proximal DVT, a higher baseline Villalta score (OR 1.23) and younger age (OR 0.96) were independent predictors of developing post-thrombotic syndrome.

View Full Paper

Ask AI

Bookmark

Why the study?

Post-thrombotic syndrome is a frequent chronic complication of proximal lower limb deep vein thrombosis, but its predictors are not well established.

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a first time acute upper femoral or iliofemoral DVT

Comparison

Patients with PTS vs without PTS

Design

Cross-sectional follow-up study

Follow-up

8-10 years

Key result

In a long-term follow-up of patients with proximal DVT, a higher baseline Villalta score (OR 1.23) and younger age (OR 0.96) were independent predictors of developing post-thrombotic syndrome.

Authors

MEMarit Engeseth TETone Enden PSPer Morten Sandset

Discussion

Member takes

Overview

Younger age and higher baseline Villalta score were associated with long-term PTS; leaves open whether these predictors should guide targeted surveillance or prevention trials.

Study Design

Type

Cross-Sectional (n=88)

Structured PICO

What are the independent predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis?

Population

88 patients with a history of first-time upper femoral or iliofemoral DVT were evaluated 8-10 years post-DVT to identify predictors of long-term post-thrombotic syndrome.

Outcome

Main Result

Odds Ratio: 1.23 (95% CI 1.02–1.49)

p-value: p=0.03

In patients with high proximal DVT, younger age and higher baseline Villalta score independently predict the development of long-term post-thrombotic syndrome.

Limitations

PTS assessment was performed using a non-validated diagnostic tool based on clinical criteria.
Only 52% of eligible patients participated, introducing potential selection bias.
A single study investigator performed all study visits and clinical assessments.
Lack of data on BMI and time in therapeutic range (TTR) prevented their evaluation as predictors.

Cite This Study

synapsesocial.com/papers/6a9199b1963a1f481f33fe98 https://doi.org/10.21203/rs.3.rs-29584/v2

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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