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January 8, 2021Thrombosis JournalOpen Access

Younger age (OR 0.96, 95% CI 0.93-0.99) and higher baseline Villalta score (OR 1.23, 95% CI 1.02-1.49) were independent predictors of long-term post-thrombotic syndrome.

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Why the study?

Post-thrombotic syndrome is a frequent chronic complication of proximal DVT of the lower limb, but its predictors are not well established.

Comparison

Predictors of PTS vs no PTS

Design

Cross-sectional follow-up study

Follow-up

8-10 years

Authors

MEMarit EngesethTETone EndenPSPer Morten Sandset

Discussion

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Member takes

Overview

Should not yet change PTS risk stratification; leaves open whether these associations warrant prospective prevention studies.

Structured PICO

P
Population
88 patients with a first-time acute upper femoral or iliofemoral DVT (from the CaVenT study), mean age 60.7 years at follow-up (50.5 at baseline), 35% female.
O
Outcome
Post-thrombotic syndrome (PTS) defined by four mandatory clinical criteria (objectively verified DVT, chronic complaints >1 month in DVT leg, complaints appeared after DVT, alternative diagnosis unlikely)composite

In patients with a history of high proximal DVT, younger age and a higher baseline Villalta score are independent predictors of developing long-term post-thrombotic syndrome.

Limitations

  • PTS assessment with no previously validated diagnostic tool
  • One study investigator performed all study visits
  • Only 52% of eligible patients participated (possible selection bias)
  • Pelvic involvement not routinely assessed in control group
  • BMI not systematically collected
  • No data on time in therapeutic range (TTR)

Cite This Study

Engeseth et al. (2021) studied this question.

synapsesocial.com/papers/6a7fe6fc112716a4cb4a08eahttps://doi.org/10.1186/s12959-020-00253-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study2020
  2. 2Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study2020 · 1 citations
  3. 3Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study2020 · 1 citations
  4. 4Post-thrombotic syndrome after early intervention in acute lower limb deep vein thrombosis: a retrospective cohort study2024
  5. 5New and known predictors of the postthrombotic syndrome: A subanalysis of the ATTRACT trial2022 · 15 citations