September 14, 2004Circulation
Newly Diagnosed and Previously Known Diabetes Mellitus and 1-Year Outcomes of Acute Myocardial Infarction
Key result
Newly diagnosed diabetes after acute myocardial infarction was associated with an increased 1-year risk of mortality (HR 1.50; 95% CI 1.21-1.85) compared to patients without diabetes.
Why the study?
Does newly diagnosed diabetes mellitus increase the risk of death and major cardiovascular events in patients with acute myocardial infarction compared to those without diabetes?
Population
14,703 patients with acute myocardial infarction enrolled in the VALIANT trial
Comparison
Newly diagnosed diabetes mellitus vs No diabetes
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
New diabetes diagnosis post-MI signals elevated death and CV event risk; extends prior associations but leaves causal screening benefits open.
Study Design
Type
Cohort (n=14,703)
Structured PICO
Does newly diagnosed diabetes mellitus increase the risk of death and major cardiovascular events in patients with acute myocardial infarction compared to those without diabetes?
P
Population
14,703 patients with acute myocardial infarction enrolled in the VALIANT trial, grouped by diabetic status and followed for 1 year.
E
Exposure
Newly diagnosed diabetes mellitus (use of diabetic therapy or diabetes diagnosed at randomization [median 4.9 days after infarction], but no known diabetes at presentation)
C
Comparator
No diabetes
O
Outcome
Death and major cardiovascular events at 1 yearhard clinical
Main Result
Hazard Ratio: 1.5 (95% CI 1.21–1.85)
Newly diagnosed diabetes after acute myocardial infarction confers a similarly high risk of 1-year mortality and cardiovascular events as previously known diabetes.
Cite This Study
Aguilar et al. (2004) conducted a cohort in Acute myocardial infarction (n=14,703). Newly diagnosed diabetes vs. No diabetes was evaluated on Mortality (HR 1.50, 95% CI 1.21 to 1.85). Newly diagnosed diabetes after acute myocardial infarction was associated with an increased 1-year risk of mortality (HR 1.50; 95% CI 1.21-1.85) compared to patients without diabetes.