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July 22, 2026Annals of General PsychiatryOpen Access

Efficacy of curcumin in depression: A grade-assessed systematic review and meta-analysis of randomized controlled trials

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Authors

VMVali MusazadehAFAmir Hossein FaghfouriMFMaryam Falahatzadeh

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Overview

Randomized trial assesses curcumin's impact on depression in adults, suggesting potential benefits but caution needed.

Key Points

  • This analysis aims to evaluate the clinical benefits of curcumin in treating depression and depressive symptoms.
  • Systematic review of databases (Scopus, PubMed, Web of Science, Embase) for randomized controlled trials.
  • Included 19 RCTs with data analyzed using a random effects model.
  • Conducted pooled analyses for eight studies on depression effects and eleven studies on depressive symptoms.
  • Curcumin supplementation significantly improved depression (SMD: -0.76; 95% CI: -1.22, -0.30, p = 0.001).
  • Curcumin also showed significant benefits for depressive symptoms (SMD: -0.53; 95% CI: -0.97, -0.09, p = 0.019).
  • No evidence of publication bias was found for either outcome.

Cite This Study

Musazadeh et al. (2026) studied this question.

synapsesocial.com/papers/6a605cf44163e025518d730ehttps://doi.org/10.1186/s12991-026-00676-z
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