Curcumin Ameliorates Depression, and Anxiety in Patients with Premenstrual Syndrome and Dysmenorrhea: A Triple-Blinded Placebo-Controlled Trial

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Background & Objective: Premenstrual syndrome (PMS) and primary dysmenorrhea (PD) are gynecological conditions that are associated with psychological and mood disorders.This study assessed the effects of curcumin, a natural polyphenol, on depression, anxiety, stress and quality of life (QL) in woman with PMS and PD. Materials & Methods:The study was undertaken in 128 women who were randomised to treatment with either curcumin (n=64) or placebo (n=64) groups.Each subject received one capsules (500 mg of curcuminoids plus 5 mg piperine, or a placebo, plus 5 mg piperine) daily, for 3 successive menstrual cycles.Psychological status and QL were assessed using Depression, Anxiety, Stress Scales-21 (DASS-21) and the Short Form-12 (SF-12) questionnaires respectively.Results: Overall scores as well as the mental health domain of the SF-12 improved significantly after curcumin supplementation (P<0.05).In addition, curcumin decreased significantly (P<0.05)all of the DASS-21 domains (depression, anxiety and stress).Significant differences were also found between the two groups for the DASS-21 domains, SF-12 mental health (total) and overall scores (P<0.05). Conclusion:Curcuminoids may be useful as a natural, widely accessible therapeutic option for the management of the psychological impact of PMS and PD, and improve the QL of women with these conditions.