Key result
VDD reprogramming resolves syncope caused by dual-chamber leadless pacing with a retained malfunctioning RV lead.
Why the study?
Can a retained malfunctioning right ventricular lead cause ventricular pacing inhibition after dual-chamber leadless pacemaker implantation?
Case Report (n=1)
Can a retained malfunctioning right ventricular lead cause ventricular pacing inhibition after dual-chamber leadless pacemaker implantation?
Retained malfunctioning leads may mediate timing-dependent ventricular inhibition after dual-chamber leadless pacing, highlighting the need for careful programming and monitoring in such patients.
Answers are grounded in this paper and cite their sources.
Potential interaction between retained leads and dual-chamber leadless pacemakers warrants caution; hypothesis-generating observation requiring prospective confirmation.
An 88-year-old pacemaker-dependent man with a retained low-impedance, noise-producing right ventricular lead underwent implantation of a dual-chamber leadless pacemaker. On postoperative day 1, he developed recurrent syncope with pauses up to 13 s. Although stored electrograms from the index events were unavailable, post-event interrogation showed atrial pacing followed by ventricular safety pacing, and provocative testing supported persistent electrical coupling involving the retained lead. After reduction of temporary high-output settings and reprogramming to VDD, syncope did not recur during 12 months. Retained malfunctioning leads may mediate timing-dependent ventricular inhibition after dual-chamber leadless pacing.
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Nakamura et al. (2026) conducted a case report in Pacemaker-dependent with a retained right ventricular lead (n=1). Dual-chamber leadless pacemaker implantation and reprogramming to VDD was evaluated on Recurrent syncope. Dual-chamber leadless pacing with a retained malfunctioning right ventricular lead caused recurrent syncope with pauses up to 13 seconds, which resolved for 12 months after reprogramming to VDD.
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