Key result
Poly-L-lysine engineering extends bioprosthetic valve durability beyond ~200 million cycles while reducing calcification and infection.
Why the study?
Bioprosthetic heart valves remain limited by progressive calcification, infection, and structural degeneration, leading to premature failure.
Does hyperbranched poly-L-lysine surface engineering improve anti-calcification, anti-infection, and durability of bioprosthetic heart valves in preclinical models?
Does hyperbranched poly-L-lysine surface engineering improve anti-calcification, anti-infection, and durability of bioprosthetic heart valves in preclinical models?
HBPL surface engineering of bioprosthetic heart valves enhances resistance to calcification and infection while maintaining durability over 200 million cycles in preclinical models.
Answers are grounded in this paper and cite their sources.
Does not yet alter clinical valve selection; leaves open human validation of HBPL durability.
Bioprosthetic heart valves (BHV) remain limited by progressive calcification, infection, and structural degeneration, leading to premature failure despite decades of clinical use. Herein, a rapid and efficient surface grafting strategy based on hyperbranched poly‐L‐lysine (HBPL) was developed to re‐engineer the pericardial interface toward improved functional performance and translational potential. The HBPL‐surface engineering enhanced the structural stability, resistance to enzymatic degradation, and anti‐calcification performance of bovine pericardium (BP). Mechanistic investigations revealed that the hyperbranched topology and dense amino functionality of HBPL regulate calcium binding behavior and inhibit the nucleation and phase transformation of amorphous calcium phosphate. In addition, HBPL modification significantly reduced bacterial adhesion while maintaining favorable cytocompatibility and hemocompatibility. Arteriovenous shunt (AV‐shunt) assays ex vivo demonstrated improved blood compatibility under flow conditions, and subcutaneous implantation in rats showed attenuated inflammatory responses and reduced calcification. Furthermore, balloon‐expandable valves fabricated from HB‐BP exhibited satisfactory hydrodynamic performance and durability exceeding 200 million fatigue cycles. Collectively, these results identify the HBPL‐based surface engineering as a simple and versatile platform for developing BHVs with enhanced resistance to calcification and infection, improved durability, and promising translational potential.
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Peng et al. (2026) studied Bioprosthetic heart valve calcification and degeneration. Hyperbranched poly-L-lysine (HBPL) surface engineering was evaluated on Calcification, infection resistance, and durability. Hyperbranched poly-L-lysine surface engineering of bioprosthetic heart valves improved resistance to calcification and infection, and demonstrated durability exceeding 200 million fatigue cycles.
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