Key result
PMEA coating of porcine pericardium improves biocompatibility and reduces calcification.
Why the study?
Thrombosis, inflammation, and calcification can lead to structural valve degeneration, limiting the durability of glutaraldehyde cross-linked bioprosthetic heart valves.
Does PMEA coating improve the biocompatibility, anti-thrombotic, and anti-calcification properties of glutaraldehyde cross-linked porcine pericardium for bioprosthetic heart valves?
Does PMEA coating improve the biocompatibility, anti-thrombotic, and anti-calcification properties of glutaraldehyde cross-linked porcine pericardium for bioprosthetic heart valves?
PMEA coating of porcine pericardium improves biocompatibility, anti-thrombotic, and anti-calcification properties, offering a potential strategy to enhance the durability of bioprosthetic heart valves.
PMEA coating merits chronic animal durability testing; leaves open translation to human bioprosthetic valves.
Commercial glutaraldehyde (Glut) cross-linked bioprosthetic heart valves (BHVs) fabricated from the pericardium have become the most popular choice for treating heart valve diseases. Nevertheless, thrombosis, inflammation and calcification might lead to structural valve degeneration (SVD), which limited the durability of BHVs. Herein, to improve the biocompatibility of BHVs, we fabricated a poly-(2-methoxyethyl acrylate) (PMEA) coated porcine pericardium (PMEA-PP) through grafting PMEA to the porcine pericardium (PP) that was pre-treated with Glut and methacrylated polylysine. PMEA coating mitigated the side effects caused by aldehyde residues. It was shown that the PMEA coating reduced cytotoxicity and inflammation reactions and improved endothelialization potential, and its hydrophilic surface improved the anti-thrombotic properties of PPs. And the PMEA coating significantly reduced the calcification of PPs. This strategy promoted the endothelialization potential and improve the anti-thrombosis and anti-calcification properties of BHVs, and is expected to overcome the defects of commercial BHVs.
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Liang et al. (2022) studied Heart valve diseases. Poly-(2-methoxyethyl acrylate) (PMEA) coating vs. Glutaraldehyde cross-linked porcine pericardium was evaluated on Biocompatibility (cytotoxicity, inflammation, endothelialization, thrombosis, calcification). Poly-(2-methoxyethyl acrylate) (PMEA) coating of porcine pericardium reduced cytotoxicity, inflammation, and calcification while improving endothelialization and anti-thrombotic properties.
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