Key result
A functionalized biological heart valve crosslinked with 2-hydroxyethyl methacrylate demonstrated mitigated immune response, reduced calcification, and enhanced antithrombogenicity in rat models.
Why the study?
To avoid and overcome the defects of glutaraldehyde-crosslinked biological heart valves.
A novel functionalized biological heart valve demonstrates improved biocompatibility, reduced calcification, and enhanced antithrombogenicity in preclinical models, suggesting potential for reducing valve degeneration.
May reduce bioprosthetic degeneration; leaves open translation to human implants.
polymerization of methacrylated porcine pericardium and 2-hydroxyethyl methacrylate to avoid and overcome the defects of glutaraldehyde-crosslinked BHVs. The functionalized BHV was proven to be stable against enzymatic degradation and compatible towards HUVECs. After implantation in rats subcutaneously, a significantly mitigated immune response and reduced calcification were observed in the functionalized BHV. With the grafting of hydrophilic 2-hydroxyethyl methacrylate polymers, the antithrombogenicity of BHV was markedly enhanced by resisting the unfavorable adhesion of blood components. Moreover, the hydrodynamics of the functionalized BHV totally conformed to ISO 5840-3 under a wide range of simulated physiological conditions. These results indicate that the functionalized BHV with enhanced biocompatibility, anticalcification property and antithrombogenicity exhibited a low risk of degeneration and should be explored for further application.
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Zheng et al. (2022) studied this question. Functionalized biological heart valve (methacrylated porcine pericardium and 2-hydroxyethyl methacrylate) vs. Glutaraldehyde-crosslinked BHVs was evaluated on Biocompatibility, antithrombogenicity, calcification, and hydrodynamics. A functionalized biological heart valve crosslinked with 2-hydroxyethyl methacrylate demonstrated mitigated immune response, reduced calcification, and enhanced antithrombogenicity in rat models.
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