Key result
A bioprosthetic heart valve treated with a hydrophilic coating of polyacrylic acid and polydimethylsiloxane exhibited better anti-biofouling properties compared to uncoated or heparin-treated valves.
Why the study?
Complications of bioprosthetic heart valves such as thrombosis, calcification, and early deterioration after implantation have limited their clinical applications.
Does a hydrophilic coating containing polyacrylic acid and polydimethylsiloxane improve anti-biofouling properties of bioprosthetic heart valves compared to uncoated or other coated valves in preclinical models?
Does a hydrophilic coating containing polyacrylic acid and polydimethylsiloxane improve anti-biofouling properties of bioprosthetic heart valves compared to uncoated or other coated valves in preclinical models?
A novel hydrophilic coating containing polyacrylic acid and polydimethylsiloxane improves the hemocompatibility and anti-calcification properties of bioprosthetic heart valve materials in preclinical models.
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New anti-biofouling BHV design shows in vitro promise; leaves open clinical translation and durability.
Yang et al. (2021) studied Bioprosthetic heart valve complications. Hydrophilic coating containing polyacrylic acid and polydimethylsiloxane vs. Uncoated BHV, heparin-treated BHV, or hydrophobic polydimethylsiloxane-coated BHV was evaluated on Anti-biofouling properties (anti-cell adhesion, resistance to protein adsorption, anticoagulant, and anti-calcification properties). A bioprosthetic heart valve treated with a hydrophilic coating of polyacrylic acid and polydimethylsiloxane exhibited better anti-biofouling properties compared to uncoated or heparin-treated valves.
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