Key result
Acute coronary syndrome significantly increased the risk of adverse outcomes (OR 2.894) in patients undergoing multiple coronary stent implantations, alongside diabetes and total stent count.
Why the study?
Factors affecting patient outcomes in multiple stent placements over a 10-year period were evaluated to determine risks of stent-related adverse events.
What factors influence stent-related adverse events in patients undergoing multiple percutaneous coronary interventions?
Observational (n=1,200)
No
What factors influence stent-related adverse events in patients undergoing multiple percutaneous coronary interventions?
Odds Ratio: 2.894 (95% CI 1.893–3.838)
Absolute Event Rate: 35% vs 12.1%
p-value: p=<0.001
In patients undergoing multiple PCIs, factors such as acute coronary syndrome, diabetes, and total stent count significantly increase the risk of stent-related adverse events over a 10-year period.
May identify risk factors for adverse events after multiple stents; leaves open need for prospective validation before practice change.
We aimed to assess the factors affecting patient outcomes in multiple stent placements over a 10-year period. The single-center study included 1,200 patients who had multiple stents implanted at least twice or more. Participants were divided into the adverse outcomes as endpoints (n = 204 [17%]) and control groups. Univariate and multivariate analyses of stent-related adverse events risk during 10 years and logistic regression analysis of the adverse outcomes risk factors were performed. Univariate analysis revealed the impact of acute coronary syndrome (ACS), diabetes mellitus, hypertriglyceridemia, cumulative lesions in the left anterior descending (LAD) and left circumflex (LCX) arteries, number of stents in the LAD, LCX, and right coronary artery (RCA), presence of multiple coronary artery lesions, total number of stents used, and intervals between the first and second and between the fourth and fifth implantations. For secondary stent implantation, significant factors in univariate analysis included the number of LAD and LCX lesions, stents in LAD, LCX, and RCA, extent of coronary lesions, ACS, hypertension, diabetes, and total stent count. Many factors affect the outcomes in this patient group over time. Reducing the need for frequent percutaneous coronary intervention and considering the number of stents implanted are essential to improving outcomes.
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Li et al. (2024) conducted an observational in Coronary heart disease with multiple stent implantations (n=1,200). Acute coronary syndrome (ACS) vs. Without acute coronary syndrome was evaluated on Adverse outcomes (death, cerebral infarction, recurrent myocardial infarction, renal failure, or combined events) (OR 2.894, 95% CI 1.893-3.838, p=<0.001). Acute coronary syndrome significantly increased the risk of adverse outcomes (OR 2.894) in patients undergoing multiple coronary stent implantations, alongside diabetes and total stent count.
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