Key result
Sickle cell trait was not associated with reduced fitness or the development of hypertension, diabetes, or metabolic syndrome in young African American adults.
Why the study?
Does sickle cell trait status affect fitness or the development of cardiovascular risk factors in young African American adults?
Cohort
Does sickle cell trait status affect fitness or the development of cardiovascular risk factors in young African American adults?
Sickle cell trait is not associated with reduced fitness or an increased risk of developing hypertension, diabetes, or metabolic syndrome in young African American adults.
Answers are grounded in this paper and cite their sources.
SCT need not alter fitness expectations or cardiometabolic screening in young African Americans; leaves open non-fitness pathways for sudden death risk.
= .28). In our secondary analysis, there was neither an association of SCT status with longitudinal changes in fitness nor an association with development of hypertension, diabetes, or metabolic syndrome after adjustment for sex, baseline age, body mass index, fitness, and physical activity. SCT is not associated with reduced fitness in this longitudinal study of young African American adults, suggesting the increased risk for exertion-related sudden death in SCT carriers is unlikely related to fitness. SCT status also is not an independent risk factor for developing hypertension, diabetes, or metabolic syndrome.
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Liem et al. (2016) conducted a cohort in Sickle cell trait. Sickle cell trait was evaluated on Reduced fitness (p=0.28). Sickle cell trait was not associated with reduced fitness or the development of hypertension, diabetes, or metabolic syndrome in young African American adults.
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