Key result
The C-Reactive Protein-albumin ratio (CAR) was significantly associated with poor heart failure outcomes, including all-cause mortality, across 1,821 patients.
Why the study?
C-reactive protein-albumin ratio is predicted to be a more reliable prognostic biomarker than CRP or albumin alone, but its role in predicting poor outcomes in heart failure needed evaluation.
Does the C-reactive protein-albumin ratio (CAR) predict poor outcomes and mortality in patients with heart failure?
Systematic Review (n=1,821)
Does the C-reactive protein-albumin ratio (CAR) predict poor outcomes and mortality in patients with heart failure?
The C-reactive protein-albumin ratio (CAR) serves as a significant prognostic biomarker for predicting mortality and adverse clinical outcomes in patients with acute and chronic heart failure.
CAR may aid HF risk stratification; hypothesis-generating for clinical use pending prospective validation.
C-Reactive Protein (CRP)-albumin ratio (CAR) is a novel prognostic biomarker that is predicted to be a more reliable indicator than CRP or albumin alone. Therefore, this systematic review aimed to evaluate the role of CAR in predicting poor outcomes of heart failure (HF) patients. We conducted a literature search across ProQuest, PubMed, ScienceDirect, Web of Science, and Scopus. All related studies assessing CAR and reporting mortality outcomes or other adverse outcomes were assessed. A total of five studies with a total of 1821 patients were included in this review. CAR is significantly associated with all-causes in-hospital mortality and out-hospital mortality in patients with acute and chronic heart failure. CAR is associated with higher hospitalization rates, the number of hospitalizations, severe New York Heart Association (NYHA) classification, and the risk of advanced HF. In conclusion, CAR is significantly associated with poor HF outcomes including all-cause mortality (cardiac and non-cardiac death).
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Kurniawan et al. (2024) conducted a systematic review in heart failure (n=1,821). C-Reactive Protein-albumin ratio (CAR) was evaluated on mortality outcomes or other adverse outcomes. The C-Reactive Protein-albumin ratio (CAR) was significantly associated with poor heart failure outcomes, including all-cause mortality, across 1,821 patients.
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