Key result
Angiovist 370 significantly reduced the incidence of ventricular fibrillation during coronary angiography compared to Renografin 76 (0.1% vs 0.6%, p<0.02).
Why the study?
Does contrast media lacking sodium citrate and EDTA reduce the incidence of ventricular fibrillation in patients undergoing coronary angiography?
Cohort (n=4,500)
Does contrast media lacking sodium citrate and EDTA reduce the incidence of ventricular fibrillation in patients undergoing coronary angiography?
Absolute Event Rate: 0.1% vs 0.6%
p-value: p=<0.02
Using contrast media lacking calcium-binding additives such as sodium citrate and EDTA significantly reduces the risk of ventricular fibrillation during coronary angiography.
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May lower VF risk during angiography with calcium-balanced contrast; leaves open relevance to modern nonionic agents.
Murdock et al. (1985) conducted a cohort in Patients undergoing coronary angiography (n=4,500). Angiovist 370 (AV370) vs. Renografin 76 (RG76) was evaluated on Contrast media-induced ventricular fibrillation (p=<0.02). Angiovist 370 significantly reduced the incidence of ventricular fibrillation during coronary angiography compared to Renografin 76 (0.1% vs 0.6%, p<0.02).
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