Key result
Unicuspid aortic valve disease is a rare condition presenting at an early life stage, requiring further large-scale prospective observational studies to establish standardized diagnostic criteria.
Why the study?
The natural history of unicuspid aortic valves remains poorly understood, and universally accepted diagnostic work-up and therapy recommendations have not yet been established.
Unicuspid aortic valve disease is a rare condition that presents earlier in life than other aortic valve diseases, and currently lacks universally accepted diagnostic and therapeutic guidelines.
INTRODUCTION: While the understanding of the pathophysiology and clinical implication of bicuspid aortic valves evolves rapidly, the natural history of unicuspid aortic valves is still poorly understood. Hence, a universally accepted diagnostic work-up process and therapy recommendations for UAV still have to be established. AREAS COVERED: This article aims to give an overview on the most recent literature addressing the pathophysiology, the diagnostic tools and appropriate surgical therapy options of unicuspid aortic valve. Due to the rare prevalence, the understanding of pathophysiology is still missing. Further, symptomatic aortic valve disease are seen much earlier life stage in this cohorts. Thus, it highlights the several surgical treatment options with pro and contra especially for the young adult cohorts. EXPERT OPINION: Large scale prospective observational studies using standardized diagnostic criteria are needed to reveal the clinical course. Further appropriate treatment strategies of unicuspid aortic valve patients is demanded.
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Naito et al. (2020) conducted a review in Unicuspid aortic valve disease. Surgical therapy was evaluated. Unicuspid aortic valve disease is a rare condition presenting at an early life stage, requiring further large-scale prospective observational studies to establish standardized diagnostic criteria.
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