Key result
Review outlines the embryology, natural history, and clinical management of bicuspid and unicuspid aortic valves.
Why the study?
Bicuspid and unicuspid aortic valves pose unique lifelong management challenges due to progressive valvular dysfunction and aortopathy, while most lifelong management literature focuses on tricuspid valve aortic stenosis.
This review provides a comprehensive framework for the lifelong management, surveillance, and intervention strategies for patients with bicuspid and unicuspid aortic valves.
Supports individualized lifelong bicuspid aortic valve care; leaves open prospective validation of surveillance strategies.
Bicuspid and unicuspid aortic valves represent the most common congenital aortic valve malformations and pose unique challenges in clinical management across the lifespan. These anomalies are associated with progressive valvular dysfunction and aortopathy, often necessitating early intervention. Multiple publications have described life-long management of aortic stenosis (AS), affecting tricuspid valve. This review outlines the embryologic basis, natural history, and clinical spectrum of uni- and bicuspid aortic valve, highlighting diagnostic strategies, surveillance protocols, and surgical - transcatheter interventions. Emphasis is placed on longitudinal care, including transition from pediatric to adult congenital cardiology, multimodality imaging, and timing of surgical or transcatheter interventions. In conclusion, the article aims to provide a framework for evidence-informed, individualized management of these complex valvulo-aortic disorders.
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Shah et al. (2025) conducted a review in Bicuspid and unicuspid aortic valves. This review outlines the embryologic basis, natural history, and clinical management of bicuspid and unicuspid aortic valves to guide individualized lifelong care.
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