Key result
Dyssynchronous electrical activation in congestive heart failure results in mechanically inefficient contraction and altered regional myocardial blood flow.
Dyssynchrony in HF with LBBB may identify CRT candidates; leaves open optimal selection and outcomes in Level 5 data.
One quarter to one third of patients with congestive heart failure have some form of intraventricular conduction abnormality that is manifested as an increased QRS duration on the electrocardiogram.1,2 The most common pattern is left bundle-branch block. In patients with left bundle-branch block, electrical activation of the lateral aspect of the left ventricle can be substantially delayed in relation to that of the right ventricle and interventricular septum. Dyssynchronous electrical activation results in dyssynchronous contraction, which is mechanically inefficient. Regional myocardial workload is distributed unequally, and regional myocardial blood flow and metabolism may be altered. As a result, the . . .
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John A. Jarcho (2005) conducted an editorial in Congestive heart failure. Dyssynchronous electrical activation in congestive heart failure results in mechanically inefficient contraction and altered regional myocardial blood flow.
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