Key result
Endogenous and exogenous natriuretic peptides (ANP and BNP) significantly reduced CYP11B2 mRNA expression in cultured neonatal rat cardiocytes (ANP, P=0.0042; BNP, P=0.0012).
Effect estimate: 1.62+/-0.12-fold increase
p-value: p=<0.0001
Endogenous and exogenous natriuretic peptides reduce CYP11B2 mRNA expression in cultured neonatal rat cardiocytes, suggesting a mechanism for inhibiting the local cardiac renin-angiotensin-aldosterone system.
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Hypothesis-generating for natriuretic peptide effects on cardiac aldosterone; leaves open translation to human therapy.
Ito et al. (2003) studied Cultured neonatal rat cardiocytes. Natriuretic peptides (ANP and BNP) and HS 142-1 vs. Angiotensin II alone was evaluated on CYP11B2 mRNA expression (1.62+/-0.12-fold increase, p=<0.0001). Endogenous and exogenous natriuretic peptides (ANP and BNP) significantly reduced CYP11B2 mRNA expression in cultured neonatal rat cardiocytes (ANP, P=0.0042; BNP, P=0.0012).
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