Key result
Intermittent weight bearing during 14 days of non-weight bearing attenuated the loss of soleus mass and partially restored type I fiber peak isometric force and maximal shortening velocity.
Why the study?
Does intermittent weight bearing attenuate non-weight-bearing-induced alterations in soleus type I fiber force and shortening velocity in adult rats?
Does intermittent weight bearing attenuate non-weight-bearing-induced alterations in soleus type I fiber force and shortening velocity in adult rats?
Absolute Event Rate: 0.31% vs 0.23%
p-value: p=<0.05
Intermittent weight bearing partially attenuates type I fiber atrophy, peak isometric force loss, and shortening velocity changes induced by 14 days of non-weight bearing in rats.
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May inform disuse countermeasures in patients; leaves open efficacy for preserving muscle properties in clinical settings.
Widrick et al. (1996) studied Muscle atrophy (hindlimb unloading) (n=21). Intermittent weight bearing (IWB) vs. Non-weight bearing (NWB) was evaluated on Type I fiber peak isometric force (mN) (p=<0.05). Intermittent weight bearing during 14 days of non-weight bearing attenuated the loss of soleus mass and partially restored type I fiber peak isometric force and maximal shortening velocity.
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