Key result
Activated Gs or its alpha subunit directly prolonged the survival of excised calcium channels and stimulated the activity of incorporated channels, independently of cytoplasmic kinases.
Why the study?
Do G proteins directly regulate mammalian cardiac calcium channels?
Population
Membrane patches excised from guinea pig cardiac myocytes and bovine cardiac sarcolemmal vesicles…
Design
Preclinical
Authors
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Supports direct G-protein modulation of cardiac Ca channels independent of cAMP; leaves open in vivo relevance and therapeutic implications.
Do G proteins directly regulate mammalian cardiac calcium channels?
Demonstrates that G proteins can directly gate mammalian cardiac calcium channels, independent of cytoplasmic kinase activation.
Yatani et al. (1987) studied this question. GTP gamma S and activated Gs or its alpha subunit was evaluated on Survival of excised calcium channels and activity of incorporated channels. Activated Gs or its alpha subunit directly prolonged the survival of excised calcium channels and stimulated the activity of incorporated channels, independently of cytoplasmic kinases.
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