Key result
Implantation of the Med-Zenith PT-Valve in patients with severe pulmonary regurgitation reduced right ventricular end diastolic volume index from 181.6 to 123.4 ml/m2 at 1 year.
Why the study?
Nearly two-thirds of patients with dilated RVOT were excluded from pulmonary valve transplantation due to a lack of size-matched valves.
Does Med-Zenith PT-Valve implantation improve hemodynamics and right ventricular volumes in patients with severe pulmonary regurgitation and dilated RVOT?
Population
22 patients with severe PR (grade 3+,4+)
Comparison
Med-Zenith PT-Valve implantation
Design
Clinical trial
Follow-up
1-year
Authors
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May support PT-Valve use in dilated RVOT; leaves open confirmation via randomized trials.
Does Med-Zenith PT-Valve implantation improve hemodynamics and right ventricular volumes in patients with severe pulmonary regurgitation and dilated RVOT?
The Med-Zenith PT-Valve demonstrates safety and feasibility for treating severe pulmonary regurgitation in patients with significantly enlarged RVOT, improving right ventricular volumes and exercise capacity at 1 year.
Shang et al. (2022) studied Severe pulmonary regurgitation (n=22). Med-Zenith PT-Valve was evaluated on Right ventricular end diastolic volume index. Implantation of the Med-Zenith PT-Valve in patients with severe pulmonary regurgitation reduced right ventricular end diastolic volume index from 181.6 to 123.4 ml/m2 at 1 year.
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