The in vivo metabolism of antithrombin III and antithrombin III complexes.

Mark A. Shifman; Salvatore V. Pizzo

doi:10.1016/s0021-9258(19)81102-x

March 1, 1982Journal of Biological ChemistryOpen Access

The in vivo metabolism of antithrombin III and antithrombin III complexes.

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to investigate the in vivo metabolism of antithrombin III and its complexes with thrombin.
Utilized 125I-labeling of antithrombin III prior to complex formation.
Analyzed interactions and complexes with mouse and human antithrombin.
Measured the impact of az-macroglobulin and protease inhibitors on metabolism.
Determined the metabolism rates of human and mouse antithrombin III.
Characterized the formation of stable complexes with thrombin.
Found significant interactions with protease inhibitors affecting metabolism.

Implication

Examines antithrombin III metabolism and its complexes, highlighting implications for treatment.

Abstract

111-thrombin complex; ~z M , az-macroglobulin; a1P1, al-protease inhibitor; m-AT, mouse antithrombin 111; h-AT, human antithrombin 111; '"I-AT-thr, '251-labeling of antithrombin 111 prior to making complex; AT-Iz5I-thr, 1251-labeling

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Shifman et al. (1982) studied this question.

synapsesocial.com/papers/6a618834ba6827eff93f5716 https://doi.org/10.1016/s0021-9258(19)81102-x

View Full Paper

Ask AI

Bookmark

Share

The in vivo metabolism of antithrombin III and antithrombin III complexes.

Key Points

Implication

Abstract

Discussion

Cite This Study

The in vivo metabolism of antithrombin III and antithrombin III complexes.

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading