Key result
Extreme nocturnal blood pressure dipping was associated with higher left ventricular mass compared to normal dipping.
Why the study?
Does extreme nocturnal blood pressure dipping status impact left ventricular mass in patients with hypertension?
Observational (n=99)
Does extreme nocturnal blood pressure dipping status impact left ventricular mass in patients with hypertension?
A larger nocturnal blood pressure drop (extreme dipping) is associated with greater left ventricular hypertrophy in hypertensive patients, which may have implications for the timing of anti-hypertensive medication dosing.
Answers are grounded in this paper and cite their sources.
Extreme dipping was associated with higher LV mass; leaves open whether dipper status should guide CMR or hypertension management.
We investigate the impact of dipper status on cardiac structure with cardiovascular magnetic resonance ( CMR ). Ambulatory blood pressure monitoring and 1.5T CMR were performed in 99 tertiary hypertension clinic patients. Subgroup analysis by extreme dipper (n = 9), dipper (n = 39), non‐dipper (n = 35) and reverse dipper (n = 16) status was performed, matched in age, gender and BMI . Left ventricular ( LV ) mass was significantly higher for extreme dippers than dippers after correction for covariates (100 ± 6 g/m 2 vs 79 ± 3 g/m 2 , P = .004). Amongst extreme dippers and dippers (n = 48), indexed LV mass correlated positively with the extent of nocturnal blood pressure dipping ( R = .403, P = .005). On post‐hoc ANCOVA , the percentage of nocturnal dip had significant effect on indexed LV mass ( P = .008), but overall SBP did not ( P = .348). In the tertiary setting, we found a larger nocturnal BP drop was associated with more LV hypertrophy. If confirmed in larger studies, this may have implications on nocturnal dosing of anti‐hypertensive medications.
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Rodrigues et al. (2018) conducted an observational in Hypertension (n=99). Extreme nocturnal blood pressure dipping vs. Normal dipping was evaluated on Left ventricular mass (p=.004). Extreme nocturnal blood pressure dipping was associated with higher left ventricular mass compared to normal dipping.
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