What question did this study set out to answer?

This study aims to investigate how l-arginine modulates nitric oxide signaling to protect against brain dysfunction caused by heat stress.

July 23, 2026Journal of Pharmacology and PharmacotherapeuticsOpen Access

l -Arginine Attenuates Brain Dysfunction in Heat-stress Rat Model via Modulating Nitric Oxide-dependent Pathway

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Authors

PJPriya Jaswal RCRishabh Chaudhary JBJhilli Basu

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Overview

Randomized trial demonstrates the neuroprotective effects of l-arginine on brain function in a heat-stress rat model, suggesting potential therapeutic applications.

Key Points

This study aims to investigate how l-arginine modulates nitric oxide signaling to protect against brain dysfunction caused by heat stress.
Induced heat stress in rats by exposure to high temperatures for 28 days.
Assessed various neurobehavioral parameters including anxiety and memory.
Measured oxidative stress, heat shock proteins, and neuroinflammatory markers using biochemical assays.
Heat-stressed rats showed significant brain injury, indicated by increased levels of stress proteins HSP70 and HSP90.
L-arginine (100 and 500 mg/kg) improved body weight and reduced oxidative stress and inflammation.
Treatment with l-arginine enhanced memory and decreased anxiety and pain sensitivity.

Cite This Study

Jaswal et al. (2026) studied this question.

synapsesocial.com/papers/6a61af8bfaa9903c5116a48e https://doi.org/10.1177/0976500x261462646

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July 23, 2026Journal of Pharmacology and PharmacotherapeuticsOpen Access

l -Arginine Attenuates Brain Dysfunction in Heat-stress Rat Model via Modulating Nitric Oxide-dependent Pathway

View Full Paper

Ask AI

Bookmark

Authors

PJPriya Jaswal RCRishabh Chaudhary JBJhilli Basu

Discussion

Member takes

Overview

Randomized trial demonstrates the neuroprotective effects of l-arginine on brain function in a heat-stress rat model, suggesting potential therapeutic applications.

Key Points

This study aims to investigate how l-arginine modulates nitric oxide signaling to protect against brain dysfunction caused by heat stress.
Induced heat stress in rats by exposure to high temperatures for 28 days.
Assessed various neurobehavioral parameters including anxiety and memory.
Measured oxidative stress, heat shock proteins, and neuroinflammatory markers using biochemical assays.
Heat-stressed rats showed significant brain injury, indicated by increased levels of stress proteins HSP70 and HSP90.
L-arginine (100 and 500 mg/kg) improved body weight and reduced oxidative stress and inflammation.
Treatment with l-arginine enhanced memory and decreased anxiety and pain sensitivity.

Cite This Study

Jaswal et al. (2026) studied this question.

synapsesocial.com/papers/6a61af8bfaa9903c5116a48e https://doi.org/10.1177/0976500x261462646

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