Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 18, 2025NutrientsOpen Access

L-Arginine Supplementation Improves Endurance Under Chronic Fatigue: Inducing In Vivo Paradigms with In Vitro Support

View Full Paper
Ask AI
Bookmark
Share

Authors

SLSomin LeeWNWoo Suk NamKAKyu Sup An

Discussion

Loading...

Member takes

Overview

L-arginine supplementation improves fatigue resistance and energy metabolism in mice, suggesting benefits for exercise recovery.

Key Points

  • L-arginine supplementation improved endurance and reduced fatigue in mice under chronic conditions.
  • Doses of 1200 mg/kg resulted in significant increases in glucose and glycogen storage while decreasing muscle injury markers.
  • Analysis of serum and tissue samples revealed enhanced antioxidant responses and altered lactate levels depending on exercise type.
  • In vitro studies indicated that l-arginine promotes myoblast differentiation and reduces oxidative stress in muscle cells.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68f408995de60f8893c6fcfdhttps://doi.org/10.3390/nu17203239
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementation of L‐Arginine, L‐Glutamine, Vitamin C, Vitamin E, Folic Acid, and Green Tea Extract Enhances Serum Nitric Oxide Content and Antifatigue Activity in Mice2020 · 8 citations
  2. 2Chronic L-Arginine Supplementation Enhances Endurance Exercise Tolerance in Heart Failure Patients2006 · 32 citations
  3. 3Acute Effects of L-Arginine Supplementation on Oxygen Consumption Kinetics and Muscle Oxyhemoglobin and Deoxyhemoglobin during Treadmill Running in Male Adults2019 · 15 citations
  4. 4Effects of Acute L-Arginine Supplementation on the Performance of Recreationally Trained Crossfit® Males: A Randomized Double-Blind Placebo-Controlled Trial2026
  5. 5Acute <scp>l</scp>-arginine supplementation reduces the O<sub>2</sub> cost of moderate-intensity exercise and enhances high-intensity exercise tolerance2010 · 131 citations