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July 23, 2026AntioxidantsOpen Access

Use of α-Cyclodextrin to Produce Nanoencapsulated Curcumin to Preserve Curcumin Stability from Photooxidation While Simultaneously Enhancing Caco-2 Intestinal Uptake and Antioxidant Capacity

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Authors

DKDavid D. KittsYGYigong GuoMSMaidinai Sabier

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Overview

Randomized trial demonstrates enhanced stability and bioavailability of curcumin in intestinal cells, suggesting improved health benefits.

Key Points

  • To improve the stability and bioavailability of curcumin through nanoencapsulation using α-cyclodextrin.
  • Developed curcumin nanoparticles using α-cyclodextrin and Tween 80.
  • Determined optimal nanoparticle size (386.4 nm) and entrapment efficiency (97.4%).
  • Conducted functional tests in differentiated Caco-2 cells.
  • Curcumin-NP stability was significantly greater (74.32%) compared to free curcumin (36.74%), p = 0.001.
  • Curcumin-NPs showed 5 times higher intestinal cellular uptake and 21.3% decrease in TEER-value compared to free curcumin (p = 0.017).
  • Curcumin-NPs exhibited higher antioxidant capacity with no cytotoxicity in Caco-2 cells.

Cite This Study

Kitts et al. (2026) studied this question.

synapsesocial.com/papers/6a61af8bfaa9903c5116a517https://doi.org/10.3390/antiox15070901
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