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July 23, 2026Gastrointestinal DisordersOpen Access

Leak-Stratified Management of Early Bile Leaks After Liver Transplantation: A Narrative Review of Leak Characteristics, Patient Stability, and the Limited Evidence on Intervention Timing in the First 14 Postoperative Days

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Authors

MSMurtaja Satea ShafeeaALAlexandre G. LellouchHOHaïzam Oubari

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Overview

Narrative review evaluates leak characteristics and patient stability in managing early bile leaks post-transplant, suggesting a framework for intervention.

Key Points

  • To determine if leak characteristics and patient stability provide more reliable guidance than intervention timing for managing early bile leaks following liver transplantation.
  • Conducted a structured narrative review using AI-assisted semantic search and PubMed/MEDLINE.
  • Included 37 sources based on a PICO framework with two independent reviewers screening the materials.
  • Focused on leak characteristics and patient stability for management insights rather than solely on timing.
  • No direct studies compared intervention timing within the first 14 postoperative days.
  • Anastomotic leaks showed higher surgical intervention rates (40%) compared to T-tube exit-site leaks (8.3%).
  • Endoscopic success rates ranged from 80% to 98% across different timing windows, indicating high effectiveness regardless of when the procedure was performed.

Cite This Study

Shafeea et al. (2026) studied this question.

synapsesocial.com/papers/6a61af8bfaa9903c5116a5aahttps://doi.org/10.3390/gidisord8030036
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