What does this research mean for the field?

Stratifying post-hepatectomy biliary leakage into early and late onset reveals distinct risk profiles, with early leakage driven by tumor proximity and prolonged operative time, whereas late leakage is primarily driven by prolonged operative time and results in higher readmission rates. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate post-hepatectomy biliary leakage by stratifying cases into early and late onset to determine whether distinct clinical profiles, risk factors, and outcomes exist.

September 5, 2026LiversOpen Access

Early Versus Late Biliary Leakage After Hepatic Resection: Incidence, Risk Profiles, and Clinical Impact of Diagnostic Timing

View Full Paper

Ask AI

Bookmark

Authors

GPGiacomo Paolini LTLuca Tirloni IBIlenia Bartolini

Discussion

Member takes

Overview

Retrospective cohort study reveals distinct risk factors and high readmission rates for late biliary leakage after hepatic resection, highlighting the need for prolonged post-discharge monitoring.

Key Points

To evaluate post-hepatectomy biliary leakage by stratifying cases into early and late onset to determine whether distinct clinical profiles, risk factors, and outcomes exist.
Retrospective cohort study of 370 patients undergoing hepatic resection between 2020 and 2024.
Patients with biliary leakage (defined by International Study Group of Liver Surgery criteria) were stratified into Early Biliary Leakage (postoperative day ≤ 7) and Late Biliary Leakage (postoperative day > 7).
Independent risk factors were identified using binary and multinomial logistic regression models.
The overall incidence of biliary leakage was 9.7% (36/370; 55.6% early, 44.4% late), with an operative time exceeding 5 hours being the sole independent predictor for overall leakage (OR = 6.9; 95% CI 2.4–19.4; p < 0.001).
Early leakage was independently predicted by tumor proximity to major intrahepatic vessels (OR = 4.1; 95% CI 1.5–11.6; p = 0.007) and operative time over 5 hours (OR = 5.2; 95% CI 1.4–19.2; p = 0.012), whereas late leakage was predicted solely by operative time over 5 hours (OR = 12.2; 95% CI 2.6–56.7; p = 0.001).
Late leakage led to higher 30-day readmission rates than early leakage (62.5% vs. 30.0%, p = 0.091), and cholangiocarcinoma was significantly more frequent among leakage cases compared to non-leakage cases (41.7% vs. 11.7%, p = 0.05).

Cite This Study

Paolini et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3e16b95aff0620eb13a https://doi.org/10.3390/livers6050088

View Full Paper

Ask AI

Bookmark

September 5, 2026LiversOpen Access

Early Versus Late Biliary Leakage After Hepatic Resection: Incidence, Risk Profiles, and Clinical Impact of Diagnostic Timing

View Full Paper

Ask AI

Bookmark

Authors

GPGiacomo Paolini LTLuca Tirloni IBIlenia Bartolini

Discussion

Member takes

Overview

Retrospective cohort study reveals distinct risk factors and high readmission rates for late biliary leakage after hepatic resection, highlighting the need for prolonged post-discharge monitoring.

Key Points

To evaluate post-hepatectomy biliary leakage by stratifying cases into early and late onset to determine whether distinct clinical profiles, risk factors, and outcomes exist.
Retrospective cohort study of 370 patients undergoing hepatic resection between 2020 and 2024.
Patients with biliary leakage (defined by International Study Group of Liver Surgery criteria) were stratified into Early Biliary Leakage (postoperative day ≤ 7) and Late Biliary Leakage (postoperative day > 7).
Independent risk factors were identified using binary and multinomial logistic regression models.
The overall incidence of biliary leakage was 9.7% (36/370; 55.6% early, 44.4% late), with an operative time exceeding 5 hours being the sole independent predictor for overall leakage (OR = 6.9; 95% CI 2.4–19.4; p < 0.001).
Early leakage was independently predicted by tumor proximity to major intrahepatic vessels (OR = 4.1; 95% CI 1.5–11.6; p = 0.007) and operative time over 5 hours (OR = 5.2; 95% CI 1.4–19.2; p = 0.012), whereas late leakage was predicted solely by operative time over 5 hours (OR = 12.2; 95% CI 2.6–56.7; p = 0.001).
Late leakage led to higher 30-day readmission rates than early leakage (62.5% vs. 30.0%, p = 0.091), and cholangiocarcinoma was significantly more frequent among leakage cases compared to non-leakage cases (41.7% vs. 11.7%, p = 0.05).

Cite This Study

Paolini et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3e16b95aff0620eb13a https://doi.org/10.3390/livers6050088

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark