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July 23, 2026British Journal of Haematology

Prognostic significance of dynamic minimal residual disease trajectories in newly diagnosed multiple myeloma

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Authors

JYJ H YuQCQi ChenMSMin Shi

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Overview

Retrospective study demonstrates MRD negativity predicts better outcomes in newly diagnosed multiple myeloma, suggesting tailored treatments could improve survival.

Key Points

  • To explore the clinical significance of dynamic MRD trajectories in newly diagnosed multiple myeloma and its implications for treatment strategies.
  • Analyzed serial MRD results from 231 newly diagnosed multiple myeloma patients achieving complete remission.
  • Examined the impact of MRD negativity on progression-free survival and overall survival with statistical analysis of hazard ratios.
  • MRD negativity predicted significantly improved progression-free survival (HR=0.222, p<0.001) and overall survival (HR=0.280, p=0.019).
  • Sustaining MRD negativity for ≥6 months was linked to improved overall survival (p<0.001).
  • Late MRD conversion showed comparable overall survival to sustained MRD negativity (p=0.339).

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a61af8bfaa9903c5116a5d6https://doi.org/10.1111/bjh.70704
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