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July 23, 2026Discover MaterialsOpen Access

A peptide library approach to biofunctionalized electrospun PLGA scaffolds for tunable endothelial cell responses

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Authors

NENursu ErdoğanECEnrica ChiesaMRMariella Rosalia

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Overview

Randomized trial evaluates tunable endothelial cell responses using peptide-functionalized PLGA scaffolds, suggesting improved biomaterial design.

Key Points

  • The aim is to engineer electrospun PLGA scaffolds using peptide motifs to improve endothelial cell responses and biocompatibility.
  • Electrospun PLGA scaffolds were functionalized with five cysteine-modified peptides using thiol coupling.
  • Cytotoxicity and biocompatibility assays were conducted on both fibroblast and endothelial cells.
  • Peptide conjugation effects on molecular and physical properties were assessed.
  • KAFDITYVRLKF induced toxicity at higher concentrations, while IKVAV, REDV, and GFOGER showed favorable biocompatibility.
  • GFOGER promoted endothelial cell proliferation more efficiently than IKVAV and REDV.
  • IKVAV and REDV mitigated the inhibitory effects on cell metabolic activity in a challenging microenvironment.

Cite This Study

Erdoğan et al. (2026) studied this question.

synapsesocial.com/papers/6a61afe0faa9903c5116a824https://doi.org/10.1007/s43939-026-00845-7
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