Key result
Early-onset type 2 diabetes was associated with subclinical left ventricular diastolic dysfunction (lower e', p<0.001) and lower lung diffusing capacity (p=0.003) compared with matched controls.
Why the study?
The study was conducted to compare cardiac and respiratory function at rest between individuals with early-onset type 2 diabetes and matched controls without diabetes.
Does early-onset type 2 diabetes affect resting cardiac and respiratory function compared to matched controls without diabetes?
Case-Control (n=32)
Does early-onset type 2 diabetes affect resting cardiac and respiratory function compared to matched controls without diabetes?
p-value: p=<0.001
Early-onset type 2 diabetes is associated with subclinical left ventricular diastolic dysfunction and reduced lung diffusing capacity compared to matched healthy controls.
Hypothesis-generating for early cardiopulmonary impairment in young type 2 diabetes; prospective studies needed before clinical adoption.
OBJECTIVES: The aim of the study was to compare cardiac and respiratory function at rest in participants with early-onset type 2 diabetes and a control group without diabetes, matched for age, sex, and body mass index (BMI). METHODS: This study included 18 participants with early-onset type 2 diabetes (12 men and 6 women, age 34.9±6 years, diabetes duration 3.1±3.0 years) and 14 control participants without diabetes, matched for age, sex, and BMI (9 men and 5 women, age 32.9±5.2 years). Participants underwent resting echocardiography and pulmonary function tests. Fasting blood samples were analyzed for glycated hemoglobin, glucose, C-reactive protein, insulin, free fatty acids, and N-terminal pro-B-type natriuretic peptide. RESULTS: Significant differences between groups were observed in left ventricular diastolic function at rest. Compared with controls, the group with early-onset type 2 diabetes had lower E/A (ratio between early [E] and late [A] ventricular filling velocity) (p=0.002), higher E/e' (representing left ventricular filling pressure) (p=0.017), lower e' (early myocardial relaxation velocity) (p<0.001), and lower diffusing capacity of the lung for carbon monoxide (p=0.003). CONCLUSIONS: Subclinical left ventricular diastolic dysfunction and lower lung diffusing capacity were detected in participants with early-onset type 2 diabetes when compared with matched controls.
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Muñoz et al. (2024) conducted a case-control in Early-onset type 2 diabetes mellitus (n=32). Early-onset type 2 diabetes mellitus vs. Matched controls without diabetes was evaluated on Left ventricular diastolic function and lung diffusing capacity (p=<0.001). Early-onset type 2 diabetes was associated with subclinical left ventricular diastolic dysfunction (lower e', p<0.001) and lower lung diffusing capacity (p=0.003) compared with matched controls.
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