Key result
Sympathomimetic amines like norepinephrine and isoproterenol may benefit systemic blood pressure in cardiogenic shock, but experimental observations suggest harmful effects on the regional myocardium.
Why the study?
Do sympathomimetic amines (norepinephrine and isoproterenol) improve hemodynamics without harming regional myocardium in cardiogenic shock?
Population
Patients with cardiogenic shock and experimental models of coronary embolization
Design
Review
Authors
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Potential myocardial harm with norepinephrine/isoproterenol in cardiogenic shock; leaves open optimal sympathomimetic selection by coronary status.
Do sympathomimetic amines (norepinephrine and isoproterenol) improve hemodynamics without harming regional myocardium in cardiogenic shock?
While sympathomimetic amines improve systemic blood pressure in cardiogenic shock, their potential harmful effects on regional myocardial blood flow warrant careful individualized investigation.
Uchida et al. (1974) conducted a review in Cardiogenic shock. Sympathomimetic amines (norepinephrine and isoproterenol) was evaluated. Sympathomimetic amines like norepinephrine and isoproterenol may benefit systemic blood pressure in cardiogenic shock, but experimental observations suggest harmful effects on the regional myocardium.
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