Key result
In vivo T2-weighted cardiac MRI on day 2 accurately determined the ischemic area at risk compared to day 0 first-pass perfusion (38.9% vs. 36.3% of left ventricular area; P=0.07).
Why the study?
Does in vivo T2-weighted cardiac MRI accurately determine the ischemic area at risk in 2-day-old nonreperfused myocardial infarction in dogs?
Does in vivo T2-weighted cardiac MRI accurately determine the ischemic area at risk in 2-day-old nonreperfused myocardial infarction in dogs?
Absolute Event Rate: 38.9% vs 36.3%
p-value: p=0.07
In vivo T2-weighted cardiac MRI can accurately determine the ischemic area at risk 2 days post-infarction in a nonreperfused canine model.
T2-weighted MRI may enable delayed area-at-risk assessment in nonreperfused infarction; leaves open human validation and clinical translation.
OBJECTIVES: To determine whether in vivo T2-weighted cardiac magnetic resonance imaging (MRI) delineates the area at risk (AAR) in 2-day-old nonreperfused myocardial infarction (MI). AAR was defined as the size of the perfusion defect on day 0. MI and the residual ischemic viable border zone comprise the AAR. MATERIALS AND METHODS: Fourteen dogs with permanent coronary artery occlusion were imaged on day 0 and day 2. The size of the AAR as measured by first-pass magnetic resonance perfusion on day 0 was compared with retrospectively determined AAR using day 2 T2-weighted MRI. Triphenyltetrazolium chloride staining was used to measure infarct size. Microspheres were used to detect residual perfusion. RESULTS: Hyperintense zones on day 2 T2-weighted magnetic resonance images accurately depicted the AAR as measured by first-pass perfusion on day 0 (38.9 +/- 3.0 vs. 36.3% +/- 3.3% of left ventricular, P = 0.07). Good correlation (R = 0.91) and Bland-Altman agreement was observed between the AAR measurements and the corresponding T2-weighted hyperintense regions. Both measures of AAR were larger than the infarcted zone (25.6% +/- 2.5% of left ventricular area; P < 0.001). CONCLUSIONS: Hyperintense regions visualized with in vivo T2-weighted cardiac MRI allow determination of the AAR 2 days postinfarction in nonreperfused MI.
No takes yet. Share an insight, caveat, or question.
Tilak et al. (2007) studied 2-day-old nonreperfused myocardial infarction (n=14). In vivo T2-weighted cardiac magnetic resonance imaging (MRI) vs. First-pass magnetic resonance perfusion was evaluated on Area at risk (AAR) as a percentage of left ventricular area (p=0.07). In vivo T2-weighted cardiac MRI on day 2 accurately determined the ischemic area at risk compared to day 0 first-pass perfusion (38.9% vs. 36.3% of left ventricular area; P=0.07).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: