Key result
Diacerein at 25 and 50 mg/kg/day ameliorated doxorubicin-induced nephrotoxicity in rats, with the higher dose showing more significant improvement across all measured parameters.
Why the study?
Does diacerein prevent doxorubicin-induced nephrotoxicity in rats?
Does diacerein prevent doxorubicin-induced nephrotoxicity in rats?
Diacerein demonstrates a dose-dependent protective effect against doxorubicin-induced nephrotoxicity in a rat model, likely mediated through its anti-inflammatory and antioxidant properties.
May protect against doxorubicin nephrotoxicity in rats; hypothesis-generating and requires clinical trials before any practice change.
Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein (DIA) on DOX-induced nephrotoxicity. DIA (25 and 50 mg/kg/day) was administered orally to rats for 15 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of DOX (15 mg/kg) at the 11th day. We measured levels of serum urea, creatinine, renal reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NO x ), catalase, and superoxide dismutase (SOD). In addition, caspase-3, tumor necrosis factor alpha (TNFα), nuclear factor kappa B (NFκB) expressions, and renal histopathology were assessed. Our results showed that DOX-induced nephrotoxicity was ameliorated or reduced by both doses of DIA, but diacerein high dose (DHD) showed more improvement than diacerein low dose (DLD). This protective effect was manifested by significant improvement in all measured parameters compared to DOX treated group by using DHD. DLD showed significant improvement of creatinine, MDA, NO x , GSH, histopathology, and immunohistochemical parameters compared to DOX treated group.
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Refaie et al. (2016) studied Doxorubicin-induced nephrotoxicity. Diacerein vs. Doxorubicin alone was evaluated on Nephrotoxicity parameters (serum urea, creatinine, GSH, MDA, NOx, catalase, SOD, caspase-3, TNFα, NFκB, histopathology). Diacerein at 25 and 50 mg/kg/day ameliorated doxorubicin-induced nephrotoxicity in rats, with the higher dose showing more significant improvement across all measured parameters.
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